Cure may be found by first of its kind Genomic sequencing of all Indians to endemic diseases

Cure may be found by first of its kind Genomic sequencing of all Indians to endemic diseases

A first of its type Genome sequencing of all 1,267 individuals from Asia, which comprises 598 individuals representing 55 ethnic groups crossing across major language classes from the Indian subcontinent, may provide key answers to finding cure for several diseases endemic to India and other Asian nations.

The GenomeAsia 100k consortium report, printed in the December 5 issue of the renowned scientific journal’Nature’, says it’s discovered over 63 million DNA variations and is an important source for identifying disease related variations in Asian-Indians. Scientists from the National Institute of Biomedical Genomics in Kalyani in West Bengal and MedGenome, a Bangalore-based genomics-driven research and diagnostics company, are part of the GenomeAsia 100k consortium project.

The practice of endogamy, marriage within select social or caste groups over 1000 years, has caused a higher burden of population-specific recessive disorders in India.

“Genomic analysis of the distinctive population groups and disorder cohorts will lead to identification of genetic mutations and drug targets not only for India but for the whole world,” said Sam Santhosh, CEO, MedGenome.

The sequence gaps, although representing only 0.1 per cent of their genomes, aids in detecting differences between humans and the differences in susceptibility to various diseases within and among population groups. The risk alters for disorders that are inherited and forecasts adverse medication effects.

The underrepresentation of non-Europeans in human genetic research so far has limited the diversity of individuals in genomic datasets and contributed to reduced medical relevance for a huge percentage of the planet’s inhabitants. Population-specific benchmark genome datasets in addition to association studies in diverse populations are needed to tackle this matter, stated the report.

The very first stage of GenomeAsia 100k, a group of population experts and bioinformatics experts, aims to accommodate 10,000 Asian people and will be accompanied by sequencing an extra 90,000 people to permit deeper evaluation of diseased and wholesome individuals.

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